Stitch, originally called Experiment 626, is a small blue alien created by a scientist named Jumbaa. He was designed to be powerful, fast, and nearly indestructible. After escaping from space prison, Stitch crash-lands on Earth, specifically, on the island of Kauaʻi in Hawaii.

There, he hides by pretending to be a dog and is adopted by a girl named Lilo. Though built for destruction, Stitch quickly shows he's also clever, curious, and full of energy. His world mixes futuristic alien technology with the tropical beauty of Hawaii, creating a unique setting where action and humor collide.